Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats
作者： Michael J Ryan , Holly J Dudash , Megan Docherty , Kenneth B Geronilla , Brent A Baker
DOI: 10.1016/J.EXGER.2010.08.002
关键词: Vitamin C 、 Ascorbic acid 、 Internal medicine 、 Isometric exercise 、 Vitamin E 、 Oxidative stress 、 Endocrinology 、 Malondialdehyde 、 Nutritional Supplementation 、 Biology 、 Antioxidant
摘要: Abstract Aging is associated with increased oxidative stress. Muscle levels of stress are further elevated exercise. The purpose this study was to determine if dietary antioxidant supplementation would improve muscle function and cellular markers in response chronic repetitive loading aging. dorsiflexors the left limb aged young adult Fischer 344 Brown × Norway rats were loaded 3 times weekly for 4.5 weeks using 80 maximal stretch–shortening contractions per session. contra-lateral served as intra-animal control. randomly assigned a diet supplemented Vitamin E C or normal non-supplemented rat chow. Biomarkers measured tibialis anterior muscle. Repetitive exercise isometric force, negative work positive rats. Only animals that C. Markers (H2O2, total GSH, GSH/GSSG ratio, malondialdehyde 8-OHdG) muscles from loading, but supplements attenuated increase. MnSOD activity animals. CuZnSOD catalase GPx endogenous enzymes after appear be regulated by post-transcriptional modifications affected differently age, exercise, supplementation. These data suggest improves indices aging output rodents.
cabdirect.org
elsevier.com
sci-hub.se 参考文章(48)
M. Leotsinidis, A. Alexopoulos, V. Schinas, M. Kardara, X. Kondakis, Plasma retinol and tocopherol levels in greek elderly population from an urban and a rural area: associations with the dietary habits. European Journal of Epidemiology. ,vol. 16, pp. 1009- 1016 ,(2000) , 10.1023/A:1010895227352
E. R. Blough, J. K. Linderman, Lack of skeletal muscle hypertrophy in very aged male Fischer 344×Brown Norway rats Journal of Applied Physiology. ,vol. 88, pp. 1265- 1270 ,(2000) , 10.1152/JAPPL.2000.88.4.1265
J. Bejma, L. L. Ji, Aging and acute exercise enhance free radical generation in rat skeletal muscle. Journal of Applied Physiology. ,vol. 87, pp. 465- 470 ,(1999) , 10.1152/JAPPL.1999.87.1.465
Francis McArdle, David M. Pattwell, Aphrodite Vasilaki, Anne McArdle, Malcolm J. Jackson, Intracellular generation of reactive oxygen species by contracting skeletal muscle cells Free Radical Biology and Medicine. ,vol. 39, pp. 651- 657 ,(2005) , 10.1016/J.FREERADBIOMED.2005.04.010
Belma Giray, Erdal Kan, Musa Bali, Filiz Hincal, Nursen Basaran, None, The effect of vitamin E supplementation on antioxidant enzyme activities and lipid peroxidation levels in hemodialysis patients. Clinica Chimica Acta. ,vol. 338, pp. 91- 98 ,(2003) , 10.1016/J.CCCN.2003.07.020
Yves Guigoz, Sylvie Lauque, Bruno J Vellas, Identifying the elderly at risk for malnutrition Clinics in Geriatric Medicine. ,vol. 18, pp. 737- 757 ,(2002) , 10.1016/S0749-0690(02)00059-9
Pamela Maher, The effects of stress and aging on glutathione metabolism. Ageing Research Reviews. ,vol. 4, pp. 288- 314 ,(2005) , 10.1016/J.ARR.2005.02.005
M. Levine, C. Conry-Cantilena, Y. Wang, R. W. Welch, P. W. Washko, K. R. Dhariwal, J. B. Park, A. Lazarev, J. F. Graumlich, J. King, L. R. Cantilena, Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 3704- 3709 ,(1996) , 10.1073/PNAS.93.8.3704
Li Li Ji, Antioxidant signaling in skeletal muscle: a brief review. Experimental Gerontology. ,vol. 42, pp. 582- 593 ,(2007) , 10.1016/J.EXGER.2007.03.002
Benedetta Bartali, Edward A. Frongillo, Jack M. Guralnik, Martha H. Stipanuk, Heather G. Allore, Antonio Cherubini, Stefania Bandinelli, Luigi Ferrucci, Thomas M. Gill, Serum Micronutrient Concentrations and Decline in Physical Function Among Older Persons JAMA. ,vol. 299, pp. 308- 315 ,(2008) , 10.1001/JAMA.299.3.308