Development of inhibitors for uPAR: blocking the interaction of uPAR with its partners
作者： Mingdong Huang , Longguang Jiang , Cai Yuan , Shujuan Yu , Zhanzhi Guo
DOI: 10.1016/J.DRUDIS.2021.01.016
关键词: Medicine 、 Translation (biology) 、 Cancer research 、 Inflammation 、 Plasminogen activator 、 Receptor 、 Urokinase receptor
摘要: Urokinase-type plasminogen activator receptor (uPAR) mediates a multitude of biological activities, has key roles in several clinical indications, including malignancies and inflammation, and, thus, attracted intensive research over the past few decades. The pleiotropic functions uPAR can be attributed to its interaction with an array partners. Many inhibitors have been developed intervene these Here, we review development classes inhibitor their inhibitory mechanisms promote translation applications.
sci-hub.st 参考文章(96)
Bernard R. Neustadt, Christine H. Blood, Elizabeth M. Smith, Derivatives of aminobenzoic and aminobiphenylcarboxylic acids useful as anti-cancer agents ,(1998)
Qiming Sun, Qian Xu, Xiangbai Dong, Lin Cao, Xiaofeng Huang, Qingang Hu, Zi-Chun Hua, A hybrid protein comprising ATF domain of pro-UK and VAS, an angiogenesis inhibitor, is a potent candidate for targeted cancer therapy. International Journal of Cancer. ,vol. 123, pp. 942- 950 ,(2008) , 10.1002/IJC.23537
Mingdong Huang, Zhuo Chen, Ke Zheng, Rui Li, Xiaolei Zhou, Yaxin Zhang, Ping Hu, Yunmei Huang, Dual actions of albumin packaging and tumor targeting enhance the antitumor efficacy and reduce the cardiotoxicity of doxorubicin in vivo. International Journal of Nanomedicine. ,vol. 10, pp. 5327- 5342 ,(2015) , 10.2147/IJN.S84478
Shafaat A Rabbani, Bushra Ateeq, Ani Arakelian, Maria Luisa Valentino, David E Shaw, Lisa M Dauffenbach, Christopher A Kerfoot, Andrew P Mazar, None, An anti-urokinase plasminogen activator receptor antibody (ATN-658) blocks prostate cancer invasion, migration, growth, and experimental skeletal metastasis in vitro and in vivo. Neoplasia. ,vol. 12, pp. 778- 788 ,(2010) , 10.1593/NEO.10296
Xiaolei Zhou, Ke Zheng, Rui Li, Zhuo Chen, Cai Yuan, Ping Hu, Jincan Chen, Jinping Xue, Mingdong Huang, None, A drug carrier targeting murine uPAR for photodynamic therapy and tumor imaging Acta Biomaterialia. ,vol. 23, pp. 116- 126 ,(2015) , 10.1016/J.ACTBIO.2015.05.017
Parastoo Tarighi, Mohammad Reza Khorramizadeh, Armin Madadkar Sobhani, Seyed Nasser Ostad, Mohammad Hossein Ghahremani, None, GROWTH INHIBITION OF MDA-MB-231 CELL LINE BY PEPTIDES DESIGNED BASED ON UPA Acta medica Iranica. ,vol. 53, pp. 403- 407 ,(2015)
Supurna Ghosh, Jeff J. Johnson, Ratna Sen, Subhendu Mukhopadhyay, Yueying Liu, Feng Zhang, Ying Wei, Harold A. Chapman, M. Sharon Stack, Functional Relevance of Urinary-type Plasminogen Activator Receptor-α3β1 Integrin Association in Proteinase Regulatory Pathways Journal of Biological Chemistry. ,vol. 281, pp. 13021- 13029 ,(2006) , 10.1074/JBC.M508526200
Ute Reuning, Stefan Sperl, Charlotte Kopitz, Horst Kessler, Achim Kruger, Manfred Schmitt, Viktor Magdolen, Urokinase-type plasminogen activator (uPA) and its receptor (uPAR): development of antagonists of uPA/uPAR interaction and their effects in vitro and in vivo. Current Pharmaceutical Design. ,vol. 9, pp. 1529- 1543 ,(2003) , 10.2174/1381612033454612
Niko Schmiedeberg, Manfred Schmitt, Christian Rölz, Vincent Truffault, Martin Sukopp, Markus Bürgle, Olaf G. Wilhelm, Wolfgang Schmalix, Viktor Magdolen, Horst Kessler, Synthesis, Solution Structure, and Biological Evaluation of Urokinase Type Plasminogen Activator (uPA)-Derived Receptor Binding Domain Mimetics Journal of Medicinal Chemistry. ,vol. 45, pp. 4984- 4994 ,(2002) , 10.1021/JM020254Q
Hyangsoon Noh, Sungguan Hong, Shuang Huang, Role of urokinase receptor in tumor progression and development. Theranostics. ,vol. 3, pp. 487- 495 ,(2013) , 10.7150/THNO.4218