Implicaciones fisiopatológicas entre inflamación crónica y el desarrollo de diabetes y obesidad
作者： José Israel León-Pedroza , Sandra Elizondo-Argueta , Gabriela Gutiérrez-Reyes , Antonio González-Chávez
DOI:
关键词: Proinflammatory cytokine 、 Inflammation 、 Disease 、 Mechanism (biology) 、 Adipose tissue 、 Diabetes mellitus 、 Medicine 、 Immune system 、 Innate immune system 、 Bioinformatics 、 Internal medicine 、 Endocrinology
摘要: The different theories about the mechanisms involved in development of metabolic disease and its complications converge presence an etiologic chronic proinflammatory state. Chronic inflammation is, at present, central pathophysiological mechanism genesis diseases. multiple interactions between immune system, adipose tissue, vascular wall pancreas are issues addressed this review, focusing on specific intracellular molecular aspects that may become new therapeutic targets. These lead to a proinflammatory, prothrombotic state as well proapoptotic endothelial damage allows atherosclerosis and, consequently, cardiovascular disease. immunopathological processes associated with etiology pathophysiology diseases is still process being fully elucidated, allowing
conferenciasindromemetabolico.org 参考文章(49)
Ajay Chawla, Yaacov Barak, Laszlo Nagy, Debbie Liao, Peter Tontonoz, Ronald M. Evans, PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nature Medicine. ,vol. 7, pp. 48- 52 ,(2001) , 10.1038/83336
Priya Mohanty, Husam Ghanim, Wael Hamouda, Ahmad Aljada, Rajesh Garg, Paresh Dandona, Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells The American Journal of Clinical Nutrition. ,vol. 75, pp. 767- 772 ,(2002) , 10.1093/AJCN/75.4.767
Ira Tabas, Macrophage death and defective inflammation resolution in atherosclerosis Nature Reviews Immunology. ,vol. 10, pp. 36- 46 ,(2010) , 10.1038/NRI2675
Ajay Chawla, William A. Boisvert, Chih-Hao Lee, Bryan A. Laffitte, Yaacov Barak, Sean B. Joseph, Debbie Liao, Laszlo Nagy, Peter A. Edwards, Linda K. Curtiss, Ronald M. Evans, Peter Tontonoz, A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis Molecular Cell. ,vol. 7, pp. 161- 171 ,(2001) , 10.1016/S1097-2765(01)00164-2
Paresh Dandona, Husam Ghanim, Ajay Chaudhuri, Sandeep Dhindsa, Sung Soo Kim, Macronutrient intake induces oxidative and inflammatory stress: potential relevance to atherosclerosis and insulin resistance. Experimental and Molecular Medicine. ,vol. 42, pp. 245- 253 ,(2010) , 10.3858/EMM.2010.42.4.033
Melek C Arkan, Andrea L Hevener, Florian R Greten, Shin Maeda, Zhi-Wei Li, Jeffrey M Long, Anthony Wynshaw-Boris, Giuseppe Poli, Jerrold Olefsky, Michael Karin, IKK-beta links inflammation to obesity-induced insulin resistance. Nature Medicine. ,vol. 11, pp. 191- 198 ,(2005) , 10.1038/NM1185
Gökhan S. Hotamisligil, Inflammation and metabolic disorders Nature. ,vol. 444, pp. 860- 867 ,(2006) , 10.1038/NATURE05485
Manuel A Gonzalez, Andrew P Selwyn, Endothelial function, inflammation, and prognosis in cardiovascular disease The American Journal of Medicine. ,vol. 115, pp. 99- 106 ,(2003) , 10.1016/J.AMJMED.2003.09.016
Tom Blanchard, Robin Bailey, Martin Holland, David Mabey, Chlamydia pneumoniae and atherosclerosis The Lancet. ,vol. 341, pp. 825- 825 ,(1993) , 10.1016/0140-6736(93)90597-A
Simone Fulda, Adrienne M. Gorman, Osamu Hori, Afshin Samali, Cellular Stress Responses: Cell Survival and Cell Death International Journal of Cell Biology. ,vol. 2010, pp. 214074- 214074 ,(2010) , 10.1155/2010/214074