Rapid Assembly of Oligosaccharides: Total Synthesis of a Glycosylphosphatidylinositol Anchor ofTrypanosoma brucei
作者： Daniel K. Baeschlin , André R. Chaperon , Virginie Charbonneau , Luke G. Green , Steven V. Ley
DOI: 10.1002/(SICI)1521-3773(19981231)37:24<3423::AID-ANIE3423>3.0.CO;2-I
关键词: Dihydropyran 、 Total synthesis 、 Chemistry 、 Reactivity (chemistry) 、 Desymmetrization 、 Convergent synthesis 、 Oligosaccharide 、 Trypanosoma brucei 、 Glycosylphosphatidylinositol anchor 、 Stereochemistry 、 General chemistry 、 Catalysis
摘要: Six building blocks, six reaction steps: The recently developed innovative methodology facilitated the convergent synthesis of complex oligosaccharide core 1 (shown here with protecting groups) for total a glycosylphosphatidylinositol (GPI) anchor. key factors are tuning reactivity blocks by using 1,2-diacetal groups and desymmetrization glycerol myo-inositol chiral bis(dihydropyran).
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