Current concepts in the treatment of rheumatoid arthritis.

作者: Daniel G. Baker , Joseph L. Rabinowitz

DOI: 10.1002/J.1552-4604.1986.TB02896.X

关键词: BioinformaticsMechanism of actionImmunologyRheumatoid arthritisDiseaseModalitiesMedicineEffective treatmentInflammationChemotherapy

摘要: The treatment of RA is complex and often frustrating. pathologic process composed acute inflammation, chronic immunologic phenomenon, connective tissue degradation. It important to understand not only the pathophysiology but also mechanism action our therapeutic drugs so that can be tailored affect aspects leading end-organ damage. Despite many available, therapy still unsatisfactory. Many work in certain patients. This could secondary variability disease state or difference drug metabolism. A better understanding both agents may lead use present development new, more effective modalities.

参考文章(114)
B. Zweiman, N. I. Abdou, S. R. Casella, Effects of azathioprine therapy on bone marrow-dependent and thymus-dependent cells in man Clinical and Experimental Immunology. ,vol. 13, pp. 55- 64 ,(1973)
Friedrich L, Zimmermann F, [Pharmacology of D-penicillamine]. Drug Research. ,vol. 25, pp. 162- ,(1975)
Emkey Rd, Nichols Je, Harris Ed, Newberg A, Low dose prednisone therapy in rheumatoid arthritis: a double blind study. The Journal of Rheumatology. ,vol. 10, pp. 713- 721 ,(1983)
N. L. Gottlieb, R. M. Stroud, Patricia I. Arnold, K. Sakai, D. R. Schultz, J. E. Volanakis, Inactivation of C1 in rheumatoid synovial fluid, purified C1 and C1 esterase, by gold compounds Clinical and Experimental Immunology. ,vol. 17, pp. 395- 406 ,(1974)
G Ekenved, G Dotevall, The absorption of acetylsalicylic acid from the stomach in relation to intragastric pH. Scandinavian Journal of Gastroenterology. ,vol. 11, pp. 801- 805 ,(1976)
Vincent T. Oliverio, Richard H. Adamson, Edward S. Henderson, The Metabolic Fate of Tritiated Methotrexate II. Absorption and Excretion in Man Cancer Research. ,vol. 25, pp. 1018- 1024 ,(1965)
Tom Tōrnroth, Bo Skrifvars, Gold Nephropathy Prototype of Membranous Glomerulonephritis American Journal of Pathology. ,vol. 75, pp. 573- 590 ,(1974)
B. D. McLeod, T. D. Kinsella, Cholestasis associated with d-penicillamine therapy for rheumatoid arthritis Canadian Medical Association Journal. ,vol. 120, pp. 965- 966 ,(1979)
A. A. H. Lawson, N. Maclean, Renal disease and drug therapy in rheumatoid arthritis. Annals of the Rheumatic Diseases. ,vol. 25, pp. 441- 449 ,(1966) , 10.1136/ARD.25.5.441
W C WALKER, V WRIGHT, Pulmonary lesions and rheumatoid arthritis. Medicine. ,vol. 47, pp. 501- 520 ,(1968) , 10.1097/00005792-196811000-00003