Sporadic ataxia with adult onset: classification and diagnostic criteria

摘要: Summary In most patients with adult-onset progressive ataxia, the condition manifests without an obvious familial background. The classification and correct diagnosis of such remain a challenge, because almost entire spectrum non-genetic genetic causes ataxia has to be considered. A wide range potential acquired exist, including chronic alcohol use, various other toxic agents, immune-mediated inflammation, vitamin deficiency, leptomeningeal deposition iron leading superficial siderosis, CNS infection. Mutations in single genes can also underlie sporadic adults. Finally, might have degenerative disease, as multiple system atrophy cerebellar type or unknown aetiology. definition clinical criteria delineation characteristic MRI features greatly facilitated early recognition ataxias. addition, specific serological markers are available that allow definite many cases.