Gonads–Müllerian Ducts

摘要: The embryonic gonad is unique and valuable in terms of the study cell-type specification, because it has capacity to develop into one two very different organs, testis or ovary. For this reason, known, before point sex determination, as "indifferent" "bipotential" gonad. This chapter describes origin urogenital ridge morphological cellular changes that occur once a sexual fate been determined. various cell types indifferent gonad, their likely origins, means by which they are induced adopt male- female-appropriate fates also described. mammalian individual ultimately determined whether not Y-chromosome, hence SRY gene, present. initiation expression yet be possible varies among species. It hypothesized Y-chromosomal male-determining factor must act solely presupporting lineage induce Sertoli differentiation. In addition, was predicted its action autonomous, although recruitment some cells through paracrine mechanism.