The residue I257 at S4-S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanols.

作者: Chang Xie , Hao-wen Liu , Na Pan , Jiu-ping Ding , Jing Yao

DOI: 10.1038/APS.2015.133

关键词: ChemistryLinkerStereochemistryResidue (chemistry)S4 s5 linkerChannel sensitivity

摘要: The residue I257 at S4–S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanols

参考文章(39)
Claire L. Padgett, Arnaud L. Lalive, Kelly R. Tan, Miho Terunuma, Michaelanne B. Munoz, Menelas N. Pangalos, José Martínez-Hernández, Masahiko Watanabe, Stephen J. Moss, Rafael Luján, Christian Lüscher, Paul A. Slesinger, Methamphetamine-evoked Depression of GABA(B) Receptor Signaling in GABA Neurons of the VTA Neuron. ,vol. 73, pp. 978- 989 ,(2012) , 10.1016/J.NEURON.2011.12.031
Steven N. Treistman, Vellareddy Anantharam, Alejandro M. Dopico, Ethanol Increases the Activity of Ca++-Dependent K+ (mslo) Channels: Functional Interaction with Cytosolic Ca++ Journal of Pharmacology and Experimental Therapeutics. ,vol. 284, pp. 258- 268 ,(1998)
Aditya Bhattacharji, Benjamin Kaplan, Thanawath Harris, Xiaoguang Qu, Markus W. Germann, Manuel Covarrubias, The concerted contribution of the S4-S5 linker and the S6 segment to the modulation of a Kv channel by 1-alkanols. Molecular Pharmacology. ,vol. 70, pp. 1542- 1554 ,(2006) , 10.1124/MOL.106.026187
M Trevisani, D Smart, M J. Gunthorpe, M Tognetto, M Barbieri, B Campi, S Amadesi, J Gray, J C. Jerman, S J. Brough, D Owen, G D. Smith, A D. Randall, S Harrison, A Bianchi, J B. Davis, P Geppetti, Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1 Nature Neuroscience. ,vol. 5, pp. 546- 551 ,(2002) , 10.1038/NN0602-852
Zahurul A. Bhuiyan, Arthur A.M. Wilde, IKs in Heart and Hearing, the Ear Can Do with Less than the Heart Circulation-cardiovascular Genetics. ,vol. 6, pp. 141- 143 ,(2013) , 10.1161/CIRCGENETICS.113.000143
Dario DiFrancesco, The Role of the Funny Current in Pacemaker Activity Circulation Research. ,vol. 106, pp. 434- 446 ,(2010) , 10.1161/CIRCRESAHA.109.208041
Jing Yao, Xiang Chen, Hui Li, Yang Zhou, Lijun Yao, Gong Wu, Xiaoke Chen, Naixia Zhang, Zhuan Zhou, Tao Xu, Houming Wu, Jiuping Ding, BmP09, a "long chain" scorpion peptide blocker of BK channels. Journal of Biological Chemistry. ,vol. 280, pp. 14819- 14828 ,(2005) , 10.1074/JBC.M412735200
Qiong-Yao Tang, Xu-Hui Zeng, Christopher J. Lingle, Closed-channel block of BK potassium channels by bbTBA requires partial activation The Journal of General Physiology. ,vol. 134, pp. 409- 436 ,(2009) , 10.1085/JGP.200910251
John J. Crowley, Steven N. Treistman, Alejandro M. Dopico, Cholesterol antagonizes ethanol potentiation of human brain BKCa channels reconstituted into phospholipid bilayers. Molecular Pharmacology. ,vol. 64, pp. 365- 372 ,(2003) , 10.1124/MOL.64.2.365