Application of intravascular ultrasound for detection and quantitation of coronary atherosclerosis.

摘要: Although angiography is widely utilized to assess the extent and severity of coronary artery disease (CAD), arteriography yields only a silhouette vessel lumen. Coronary intravascular ultrasound supplements by providing tomographic perspective lumen geometry wall structure. Intracoronary can now be performedin vivo utilizing small, flexible probes capable negotiating tortuous vessles. We have performed in more than 100 patients, including group normal subjects, with no serious complications. Measurements dimensions correlated closely for vessels (r=0.92) concentrically narrowed atherosclerotic (r=0.90). However, correlation between was fair eccentrically arteries (r=0.79) poor following angioplasty (r=0.30). motion measured demonstrated significant differences (18% area change) (11% change). important structure altherosclerotic walls. Arteries subjects exhibited thin intimal leading-edge echo (mean 0.20 mm) subadjacent sonolucent zone 0.12 mm). Atherosclerotic typically increased thickness both structures often dense fibrocalcific plaques that shadowed underlying anatomy. These abnormalities were present at angiographically sites. Several limitations apparent, ‘dropout’, distortions produced non-coaxial imaging, inability image small or severely vessels. holds great promise detection quantification CAD clinical setting.