Computer-aided design for metabolic engineering
作者： Alfred Fernández-Castané , Tamás Fehér , Pablo Carbonell , Cyrille Pauthenier , Jean-Loup Faulon
DOI: 10.1016/J.JBIOTEC.2014.03.029
关键词: CAD 、 Process (engineering) 、 Pipeline (software) 、 Techniques of genetic engineering 、 Computer science 、 Computer Aided Design 、 Synthetic biology 、 Metabolic engineering 、 Bioprocess 、 Biochemical engineering
摘要: The development and application of biotechnology-based strategies has had a great socio-economical impact is likely to play crucial role in the foundation more sustainable efficient industrial processes. Within biotechnology, metabolic engineering aims at directed improvement cellular properties, often with goal synthesizing target chemical compound. use computer-aided design (CAD) tools, along continuously emerging advanced genetic techniques have allowed broaden streamline process heterologous compound-production. In this work, we review CAD tools available for an emphasis, on retrosynthesis methodologies. Recent advances pathway implementation optimization are also reviewed as well range bionalytical validate silico predictions. A case study applying presented experimental verification output from Retropath, first complete automated computational pipeline applicable engineering. Applying pipeline, together reassembly culture conditions led improved production plant flavonoid pinocembrin. Coupling bioprocess enhanced product yields will be value non-natural products through biotechnological
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