Biocatalytic resolution of benzyl glycidyl ether and its derivates by Talaromyces flavus: effect of phenyl ring substituents on enantioselectivity
作者： Chun Wei , Yunyun Chen , Honglei Shen , Shan Wang , Lin Chen
DOI: 10.1007/S10529-012-0927-2
关键词: Ring (chemistry) 、 Enantiomer 、 Glycidyl ether 、 Resolution (mass spectrometry) 、 Stereochemistry 、 Fermentation 、 Talaromyces flavus 、 Chemistry 、 Epoxide hydrolase
摘要: Talaromyces flavus containing a constitutive epoxide hydrolase (EH) resolved racemic benzyl glycidyl ether and nine derivatives into their (R)-enantiomers. After optimization of the fermentation conditions, specific EH activity biomass concentration were improved from 13.5 U/g DCW 14.8 g DCW/l to 26.2 31.3 DCW/l, respectively, with final values for e.e.s 96 % E 13 (R)-benzyl ether. Substituents on phenyl ring, however, gave low enantioselectivities.
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