Catabolite repression of the citST two-component system in Bacillus subtilis
作者： Guillermo D. Repizo , VÃctor S. Blancato , Pablo D. Sender , Juke Lolkema , Christian Magni
DOI: 10.1111/J.1574-6968.2006.00318.X
关键词: Biology 、 Catabolite repression 、 Promoter 、 General transcription factor 、 Transcription factor 、 Molecular biology 、 Psychological repression 、 CCPA 、 Bacillus subtilis 、 Operon
摘要: In Bacillus subtilis, expression of the citrate transporter CitM is under strict control. Transcription citM gene induced by in medium mediated CitS-CitT two-component system and repressed rapidly degraded carbon sources catabolite repression (CCR). this study, we demonstrate that citST genes are part a bicistronic operon. The promoter region was localized stretch 58 base pairs upstream citS deletion experiments. operon presence glucose general transcription factor CcpA. A distal consensus cre site citS-coding sequence implicated mechanism repression. Furthermore, relieved subtilis mutants deficient CcpA or Hpr/Crh, components essential to CCR. Thus, CCR represses operon, which responsible for induction citM, through located 1326 bp from transcriptional start citST.
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