Intraperitoneal chemohyperthermia using a closed abdominal procedure and cytoreductive surgery for the treatment of peritoneal carcinomatosis: morbidity and mortality analysis of 216 consecutive procedures.

作者: O. Glehen , D. Osinsky , E. Cotte , F. Kwiatkowski , G. Freyer

DOI: 10.1245/ASO.2003.01.018

关键词: Cytoreductive surgeryProspective cohort studyCombined Modality TherapySurgical oncologyTreatment outcomeMedicineIntraperitoneal chemotherapyPeritoneal carcinomatosisSurgeryPeritoneal Surface Malignancy

摘要: Background: Peritoneal carcinomatosis has been regarded as a lethal clinical entity. Recently, aggressive treatments combining intraperitoneal chemohyperthermia (IPCH) with cytoreductive surgery have resulted in long-term survival selected patients. The aim of this trial was to analyze the mortality and morbidity 216 consecutive peritoneal by IPCH using closed abdominal procedure combined surgery.

参考文章(19)
J Bienvenu, B Salle, G Panteix, P Y Carry, A Brachet, A C Sayag, B Guibert, G Burgard, F N Gilly, V Banssillon, Regional chemotherapy (with mitomycin C) and intra-operative hyperthermia for digestive cancers with peritoneal carcinomatosis. Hepato-gastroenterology. ,vol. 41, pp. 124- 129 ,(1994)
Annie C Beaujard, Olivier Glehen, Jean L Caillot, Yves Francois, Jacques Bienvenu, Gilles Panteix, Florence Garbit, Eric Grandclément, Jacques Vignal, François N Gilly, None, Intraperitoneal chemohyperthermia with mitomycin C for digestive tract cancer patients with peritoneal carcinomatosis Cancer. ,vol. 88, pp. 2512- 2519 ,(2000) , 10.1002/1097-0142(20000601)88:11<2512::AID-CNCR12>3.0.CO;2-J
F. N. Gilly, P. Y. Carry, A. C. Sayag, G. Panteix, M. Manchon, A. Rochette, J. L. Peix, J. Baulieux, I. James, G. Braillon, Tolerance of intraperitoneal chemohyperthermia with mitomycin C: in vivo study in dogs. International Journal of Hyperthermia. ,vol. 8, pp. 659- 666 ,(1992) , 10.3109/02656739209038001
G. Panteix, M. Guillaumont, L. Cherpin, J. Cuichard, F.N. Gilly, P.Y. Carry, A. Sayag, B. Salle, A. Brachet, J. Bienvenu, P. Baltassat, G. Braillon, Study of the Pharmacokinetics of Mitomycin C in Humans during Intraperitoneal Chemohyperthermia with Special Mention of the Concentration in Local Tissues Oncology. ,vol. 50, pp. 366- 370 ,(1993) , 10.1159/000227211
Arvil D. Stephens, Robert Alderman, David Chang, Gary D. Edwards, Jesus Esquivel, Gilbert Sebbag, Mark A. Steves, Paul H. Sugarbaker, Morbidity and mortality analysis of 200 treatments with cytoreductive surgery and hyperthermic intraoperative intraperitoneal chemotherapy using the coliseum technique. Annals of Surgical Oncology. ,vol. 6, pp. 790- 796 ,(1999) , 10.1007/S10434-999-0790-0
Francesco Cavaliere, Pasquale Perri, Franco Di Filippo, Diana Giannarelli, Claudio Botti, Maurizio Cosimelli, Manfredo Tedesco, Francesca Principi, Lamberto Laurenzi, Renato Cavaliere, Treatment of peritoneal carcinomatosis with intent to cure Journal of Surgical Oncology. ,vol. 74, pp. 41- 44 ,(2000) , 10.1002/1096-9098(200005)74:1<41::AID-JSO10>3.0.CO;2-R
A.J. Witkamp, E. de Bree, M.M. Kaag, H. Boot, J.H. Beijnen, G.W. van Slooten, F. van Coevorden, F.A.N. Zoetmulder, Extensive cytoreductive surgery followed by intra-operative hyperthermic intraperitoneal chemotherapy with mitomycin-C in patients with peritoneal carcinomatosis of colorectal origin European Journal of Cancer. ,vol. 37, pp. 979- 984 ,(2001) , 10.1016/S0959-8049(01)00058-2