Discriminative Stimulus Properties of Ethanol in the Rat: Differential Effects of Selective and Nonselective Benzodiazepine Receptor Agonists
作者： Przemyslaw Bienkowski , Krystyna Iwinska , Roman Stefanski , Wojciech Kostowski
DOI: 10.1016/S0091-3057(97)00034-8
关键词: Benzodiazepine 、 Stimulation 、 Agonist 、 Pharmacology 、 Abecarnil 、 Bretazenil 、 Diazepam 、 Chemistry 、 Zolpidem 、 Internal medicine 、 Receptor 、 Endocrinology
摘要: Rats were trained to discriminate between ethanol (1.0 g/kg; 10% v/v) and saline under a fixed ratio 10 schedule of sweetened milk reinforcement. Both diazepam [nonselective, full benzodiazepine (BZ) receptors agonist] bretazenil (nonselective, partial BZ receptor agonist) produced dose-dependent ethanol-appropriate responding (>75%). Neither nor affected the response rate at doses producing maximal generalisation from ethanol. In contrast, zolpidem (full BZ1 abecarnil BZ1/full or BZ2 only moderate (<50%) when tested up that markedly decreased overall rate. These results suggest that: 1) there are no major differences partial, nonselective agonists in their ability substitute for 1.0 g/kg dose ethanol; 2) stimulation alone is not sufficient produce ethanol-like discriminative stimulus effects rat.
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