Prognostic relevance of UCH-L1 and α-internexin in pancreatic neuroendocrine tumors.

摘要: Prognostic biomarkers for the pancreatic neuroendocrine tumors are needed. Proteomic study on insulinoma has been rarely reported. We identified differential expression of proteins between and their paired tissues by proteomic analysis, evaluated prognostic significance specific in including insulinoma. The select was validated more than 300 using immunohistochemical staining western blot. Methylation UCH-L1 promoter examined methylation PCR sequencing. concurrent α-internexin correlated with prognosis 2 independent collectives patients tumors. Sixty-two 219 were significantly down-regulated up-regulated insulinomas, respectively. Demethylation associated (p = 0.002). better overall survival disease-free combination both cohorts (log rank p = 3.90 × 10−4 p = 3.75 × 10−5, respectively) each cohorts. value also stage II III (p = 0.017 p = 0.006, respectively). could be