Multi-Layer Self-Nanoemulsifying Pellets: an Innovative Drug Delivery System for the Poorly Water-Soluble Drug Cinnarizine.

摘要: Beside their solubility limitations, some poorly water-soluble drugs undergo extensive degradation in aqueous and/or lipid-based formulations. Multi-layer self-nanoemulsifying pellets (ML-SNEP) introduce an innovative delivery system based on isolating the drug from layer to enhance and minimize degradation. In current study, various batches of cinnarizine (CN) ML-SNEP were prepared using fluid bed coating involved a drug-free layer, protective moisture-sealing anti-adherent layer. Each was optimized outcomes such as recovery mono-pellets%. The characterized scanning electron microscopy (SEM), differential calorimetry (DSC), X-ray diffraction (XRD), vitro dissolution, stability studies. free-flowing, well separated with high recovery. SEM showed multiple well-defined layers. acidic polyvinylpyrrolidone:CN (4:1) solution presented excellent drug-layering outcomes. DSC XRD confirmed CN transformation into amorphous state within isolation between did not adversely affect dissolution. able spontaneously migrate micelles arising the drug-free superior dissolution compared Stugeron® tablets at pH 1.2 6.8. Particularly, shifting 6.8, maintained > 84% while significant precipitation leaving only 7% solution. Furthermore, (comprising Kollicoat® Smartseal 30D) robust > 97% intact accelerated storage conditions. Accordingly, offer novel that combines both enhanced solubilization stabilization unstable soluble drugs.