CuBr-catalyzed direct indolation of tetrahydroisoquinolines via cross-dehydrogenative coupling between sp3 C-H and sp2 C-H bonds.

作者： Zhiping Li , Chao-Jun Li

关键词: Reagent 、 Medicinal chemistry 、 Copper bromide 、 Catalysis 、 Coupling (electronics) 、 Bicyclic molecule 、 Chemistry 、 Dehydrogenation 、 Stereochemistry 、 Oxidizing agent 、 Reaction mechanism

摘要: A novel and efficient C-C bond formation method was developed via the cross-dehydrogenative coupling (CDC) reaction of indoles tetrahydroisoquinolines catalyzed by copper bromide in presence an oxidizing reagent, tert-BuOOH. The CDC provides a simple catalytic to construct indolyl combination sp3 C-H sp2 followed formation.