Ablation of neuronal ADAM17 impairs oligodendrocyte differentiation and myelination.

摘要: Myelin, one of the most important adaptations vertebrates, is essential to ensure efficient propagation electric impulse in nervous system and maintain neuronal integrity. In central (CNS), development oligodendrocytes process myelination are regulated by coordinated action several positive negative cell-extrinsic factors. We others previously showed that secretases regulate activity proteins for myelination. now report α-secretase ADAM17 controls oligodendrocyte differentiation myelin formation CNS. Ablation Adam17 neurons impairs vivo vitro differentiation, delays throughout results hypomyelination. Furthermore, we show this developmental defect is, part, result altered Notch/Jagged 1 signaling. Surprisingly, conditional loss immature has no effect on formation. Collectively, our data indicate required proper CNS Further, studies confirm post-translational regulators although mechanisms controlling peripheral (PNS) distinct.