Targeting Prolactin Receptor (PRLR) Signaling in PRLR-Positive Breast and Prostate Cancer
作者： Ciara C. O'Sullivan , Susan E. Bates
DOI: 10.1634/THEONCOLOGIST.2016-0108
关键词: Signal transduction 、 Antitumor activity 、 Prolactin 、 Prolactin receptor 、 In patient 、 Receptor 、 Oncology 、 Medicine 、 Prostate cancer 、 Internal medicine
摘要: In this issue of The Oncologist, Agarwal et al. report negative results from a phase I trial LFA102. Although “negative” in terms antitumor activity, the study provides useful pharmacokinetic and pharmacodynamic information. Future trials evaluating PRLR blockers alone combination with other agents may still be warranted patients breast prostate cancer.
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