Hydrogel releases drug in two steps

摘要: AHYDROGEL-DRUG SYSTEM that relies on the consecutive action of two trigger mechanisms to release a drug has potential target specific sites within body according scientists in Netherlands who developed system. The triggers are stimulus converts gel into solution and an enzyme cleaves hydrogelator- link. "Raising temperature or lowering pH causes more low-molecular-weight gelator molecules come out fibers go solution," says Kjeld J. C van Bommel, researcher at Biomade Technology Foundation, Groningen, carried work with Jan Esch, assistant professor chemistry University coworkers ( Org. Biomol. Chem. 2005,3,2917). "Only when they can be cleaved by released," Bommel continues. "The combination sensitive both its environment ...