[Motor complications of treatment with levodopa in Parkinson's disease].

摘要: INTRODUCTION Motor complications of treatment with levodopa affect more than 50% patients after several years' treatment. This has a marked effect on Parkinson's disease since these side effects are undesirable, the natural course disorder and complicate DEVELOPMENT In this review we describe main epidemiological, physiopathological therapeutic aspects motor levodopa. According to most epidemiological studies, starting at an early age severe degree risk factors. The physiopathology is varied. It been thought be due loss buffer brain plasma levels levodopa, alterations in functional state postsynaptic receptors chronic intermittent use Management includes division and/or reduction dose slow-release preparations association dopaminergic agonists COMT inhibitors which latest drugs tried. Various surgical possibilities specialist centres may also considered for serious cases do not respond medical CONCLUSIONS Recent advances understanding permit improved control