Twist1 correlates with poor differentiation and progression in gastric adenocarcinomaviaelevation of FGFR2 expression
作者： Dong-Yuan Zhu
DOI: 10.3748/WJG.V20.I48.18306
关键词: Cancer 、 Real-time polymerase chain reaction 、 Biology 、 Adenocarcinoma 、 Cancer research 、 Twist transcription factor 、 Cellular differentiation 、 Gene knockdown 、 Fibroblast growth factor receptor 2 、 Epithelial–mesenchymal transition 、 Pathology
摘要: AIM: To explore the correlation between Twist-related protein (Twist)1, fibroblast growth factor receptor (FGFR)2 and gastric adenocarcinoma differentiation progression. METHODS: We evaluated Twist1 FGFR2 in 52 samples by immunohistochemistry quantitative real time polymerase chain reaction, analyzed Twist1, cancer differentiation. also detected expression cell lines, influence on expression. In addition, we studied role of Twist1-promoted progression, including proliferation, invasion epithelial-mesenchymal transition (EMT). RESULTS: were almost all samples. (P = 0.0213) 0.0310) mRNA levels had a significant association with Moreover, poorly differentiated cells (SNU-1 SNU-16) was notably higher than well-differentiated (MKN-7 MKN-28). adenocarcinomas, level significantly positively correlated 0.004). proved to promote regulating knockdown overexpression. Additionally, could induce EMT cancer; these, required for EMT, rather proliferation. CONCLUSION: are highly associated adenocarcinoma; can facilitate via promotion
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