Predicting in vitro drug sensitivity using Random Forests
作者： Gregory Riddick , Hua Song , Susie Ahn , Jennifer Walling , Diego Borges-Rivera
DOI: 10.1093/BIOINFORMATICS/BTQ628
关键词: In vitro 、 Computational biology 、 Gene expression 、 Random forest 、 Statistical model 、 Computer science 、 Gene expression profiling 、 Sensitivity (control systems) 、 Bioinformatics 、 Regression analysis
摘要: … To improve on this approach, we used gene expression signature generated by fitting a regression model between drug IC50 and basal gene expression using Random Forest. This …
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Matthew Wiener, Andy Liaw, Classification and Regression by randomForest ,(2007)
Ramón Díaz-Uriarte, Sara Alvarez de Andrés, Gene selection and classification of microarray data using random forest BMC Bioinformatics. ,vol. 7, pp. 3- 3 ,(2006) , 10.1186/1471-2105-7-3
Vanicha Vichai, Kanyawim Kirtikara, Sulforhodamine B colorimetric assay for cytotoxicity screening Nature Protocols. ,vol. 1, pp. 1112- 1116 ,(2006) , 10.1038/NPROT.2006.179
J. K. Lee, D. M. Havaleshko, H. Cho, J. N. Weinstein, E. P. Kaldjian, J. Karpovich, A. Grimshaw, D. Theodorescu, A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 13086- 13091 ,(2007) , 10.1073/PNAS.0610292104
Seiichi Mori, Jeffrey T. Chang, Eran R. Andrechek, Anil Potti, Joseph R. Nevins, Utilization of Genomic Signatures to Identify Phenotype-Specific Drugs PLoS ONE. ,vol. 4, pp. e6772- ,(2009) , 10.1371/JOURNAL.PONE.0006772
Robert H. Shoemaker, The NCI60 human tumour cell line anticancer drug screen Nature Reviews Cancer. ,vol. 6, pp. 813- 823 ,(2006) , 10.1038/NRC1951
K. D. Paull, R. H. Shoemaker, L. Hodes, A. Monks, D. A. Scudiero, L. Rubinstein, J. Plowman, M. R. Boyd, Display and Analysis of Patterns of Differential Activity of Drugs Against Human Tumor Cell Lines: Development of Mean Graph and COMPARE Algorithm Journal of the National Cancer Institute. ,vol. 81, pp. 1088- 1092 ,(1989) , 10.1093/JNCI/81.14.1088
John N. Weinstein, Spotlight on molecular profiling: “Integromic” analysis of the NCI-60 cancer cell lines Molecular Cancer Therapeutics. ,vol. 5, pp. 2601- 2605 ,(2006) , 10.1158/1535-7163.MCT-06-0640
Anil Potti, Holly K Dressman, Andrea Bild, Richard F Riedel, Gina Chan, Robyn Sayer, Janiel Cragun, Hope Cottrill, Michael J Kelley, Rebecca Petersen, David Harpole, Jeffrey Marks, Andrew Berchuck, Geoffrey S Ginsburg, Phillip Febbo, Johnathan Lancaster, Joseph R Nevins, None, Genomic signatures to guide the use of chemotherapeutics. Nature Medicine. ,vol. 12, pp. 1294- 1300 ,(2006) , 10.1038/NM1491
J. E. Staunton, D. K. Slonim, H. A. Coller, P. Tamayo, M. J. Angelo, J. Park, U. Scherf, J. K. Lee, W. O. Reinhold, J. N. Weinstein, J. P. Mesirov, E. S. Lander, T. R. Golub, Chemosensitivity prediction by transcriptional profiling Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 10787- 10792 ,(2001) , 10.1073/PNAS.191368598