Treatment of Patients With Metastatic Urothelial Cancer “Unfit” for Cisplatin-Based Chemotherapy
作者： Matthew D. Galsky , Noah M. Hahn , Jonathan Rosenberg , Guru Sonpavde , Thomas Hutson
关键词: Metastasis 、 Clinical trial 、 Cisplatin 、 Oncology 、 Genitourinary system 、 Combination chemotherapy 、 Internal medicine 、 Cancer 、 Metastatic Urothelial Carcinoma 、 Medicine 、 Chemotherapy
摘要: Purpose Cisplatin-based combination chemotherapy is considered standard first-line treatment for patients with metastatic urothelial carcinoma. However, a large proportion of carcinoma are “unfit” cisplatin. The purpose this review to define unfit and identify options subgroup patients. Patients Methods In review, the criteria used explored results prospective clinical trials evaluating chemotherapeutic regimens in summarized. Results Several phase II single, III trial have Heterogeneous eligibility been these studies. A uniform definition proposed on basis survey genitourinary medical oncologists. According definition, unfit...
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