Characteristics of vestibular corrective saccades in patients with slow visual saccades, vestibular disorders and controls: A descriptive analysis.

作者: Dario Andres Yacovino , Leigh Alexander Martin , Manuel Perez Akly , Timothy Carl Hain

DOI: 10.1371/JOURNAL.PONE.0197079

关键词: MedicineAudiologySaccadic maskingHead impulse testPeripheralSaccadeEye movementIn patientVestibular systemBrainstem

摘要: Objective Our aim was to determine whether overt catch up saccades (OS) provoked by vestibular stimuli, as observed in the video head impulse test (vHIT), have comparable metrics visually triggered horizontal (VS), indicating a common saccadic brainstem generator. Methods Three groups of patients were studied: with neurological disorders causing slow (group 1, n = 12), peripheral lesions 2, 43), and normal controls 3, 24). All underwent vHIT Videooculographic testing. OS velocity, acceleration, amplitude duration VS velocity this group compared between groups. Results There significant reduction guided expected from patient selection constraints study. Group 1 also exhibited which longer reduced acceleration when subjects without slowing visual targets (Group 2 3). There positive correlations both saccade (2 3) not (1). Conclusions The measured are similar saccades. This supports hypothesis that associated stimuli share circuitry metrics.

参考文章(31)
A T Bahill, A Brockenbrough, B T Troost, Variability and development of a normative data base for saccadic eye movements. Investigative Ophthalmology & Visual Science. ,vol. 21, pp. 116- 125 ,(1981)
K A Bahill, L Stark, A T Bahill, M R Clark, Closely spaced saccades. Investigative Ophthalmology & Visual Science. ,vol. 14, pp. 317- 321 ,(1975)
Benjamin Mossman, Stuart Mossman, Gordon Purdie, Erich Schneider, Age dependent normal horizontal VOR gain of head impulse test as measured with video-oculography Journal of Otolaryngology-head & Neck Surgery. ,vol. 44, pp. 29- 29 ,(2015) , 10.1186/S40463-015-0081-7
Pichet Termsarasab, Thananan Thammongkolchai, Janet C. Rucker, Steven J. Frucht, The diagnostic value of saccades in movement disorder patients: a practical guide and review Journal of Clinical Movement Disorders. ,vol. 2, pp. 14- 14 ,(2015) , 10.1186/S40734-015-0025-4
Klaus G. Rottach, Regina D. Von Maydell, Vallabh E. Das, Ari Z. Zivotofsky, Alfred O. Discenna, Jacob L. Gordon, Dennis M.D. Landis, R. John Leigh, Evidence for independent feedback control of horizontal and vertical saccades from Niemann-Pick type C disease Vision Research. ,vol. 37, pp. 3627- 3638 ,(1997) , 10.1016/S0042-6989(96)00066-1
P. Federighi, G. Cevenini, M. T. Dotti, F. Rosini, E. Pretegiani, A. Federico, A. Rufa, Differences in saccade dynamics between spinocerebellar ataxia 2 and late-onset cerebellar ataxias Brain. ,vol. 134, pp. 879- 891 ,(2011) , 10.1093/BRAIN/AWR009
H. G. MacDougall, K. P. Weber, L. A. McGarvie, G. M. Halmagyi, I. S. Curthoys, The video head impulse test Diagnostic accuracy in peripheral vestibulopathy Neurology. ,vol. 73, pp. 1134- 1141 ,(2009) , 10.1212/WNL.0B013E3181BACF85
Chris R. S. Kaneko, Albert F. Fuchs, Effect of pharmacological inactivation of nucleus reticularis tegmenti pontis on saccadic eye movements in the monkey. Journal of Neurophysiology. ,vol. 95, pp. 3698- 3711 ,(2006) , 10.1152/JN.01292.2005
Sylvan Kornblum, David E. Meyer, Richard A. Abrams, Speed and accuracy of saccadic eye movements: characteristics of impulse variability in the oculomotor system. Journal of Experimental Psychology: Human Perception and Performance. ,vol. 15, pp. 529- 543 ,(1989) , 10.1037//0096-1523.15.3.529