1,2,3-Triazoles and the Expanding Utility of Charge Neutral CH···Anion Interactions

摘要: As the field of anion supramolecular chemistry continues to grow in its sophistication and understanding noncovalent interactions used effectively bind anions, there exists new theoretical experimental evidence for a necessary reexamination way which views hydrogen bond donors. The heteroatom based hydrogen-bond donors (e.g., NH OH) are well-known provide strong stabilization negatively charged species. However, findings point untapped energy that lay dormant extrinsically-activated CH bonds. Computational studies showed an activated aliphatic or aromatic can amount gas phase approaching conventional Discovery Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition 1,2,3-triazoles ability readily “click” this functionality into receptors has allowed extensive investigation ideas posed by these calculations. This chapter will focus on evolution from being viewed as weak, secondary interaction now utilized powerful source macrocyclic oligomeric receptors. In addition, application binding power 1,2,3-triazole towards preparation mechanically interlocked structures also be discussed.