Pertussis toxin-sensitive heterotrimeric G(αi/o) proteins mediate WNT/β-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A.
作者： Carina Halleskog , Gunnar Schulte
DOI: 10.1016/J.CELLSIG.2012.12.006
关键词: Cell biology 、 Wnt signaling pathway 、 LRP5 、 Proinflammatory cytokine 、 LRP6 、 Biology 、 Frizzled 、 Pertussis toxin 、 Catenin 、 Heterotrimeric G protein
摘要: … that (i) WNT-3A/LRP6 interaction is not required for the WNT-3A-induced formation of PS-DVL3 and Gβγ-dependent phosphorylation of ERK1/2, and that (ii) WNT-3A induces PS-DVL3 …
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