Antioxidant and anti-inflammatory effects of cauliflower leaf powder-enriched diet against LPS induced toxicity in rabbits
作者： Marilena Larocca , Anna Maria Perna , Amalia Simonetti , Emilio Gambacorta , Alessandra Iannuzzi
DOI: 10.1039/C7FO00253J
关键词: Oxidative stress 、 Superoxide dismutase 、 Biology 、 Immunology 、 Toxicity 、 TBARS 、 Glutathione 、 Catalase 、 Pharmacology 、 Antioxidant 、 Thiobarbituric acid
摘要: Brassica phytochemicals exert a broad spectrum of health-promoting activities. The aim this study was to investigate the possible beneficial effects cauliflower leaf powder (CLP)-enriched diet prevent inflammation and oxidative stress resulting from injection lipopolysaccharide (LPS) into rabbits. Animals (24 rabbits) were randomly divided two groups fed with standard (SD) or supplemented 100 g kg-1 CLP. After 60 days, six rabbits both received LPS (100 μg per kg body weight). Serum samples collected after 90 min assessed for their content inflammatory biomarkers such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) matrix-metalloproteinases (MMP-2 MMP-9) thiobarbituric acid reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD) catalase (CAT). increased levels TNF-α, IL-6, TBARS well MMP-2 MMP-9 activities, whereas it decreased GSH SOD CAT In conclusion, preventive supplementation CLP can protect induced by LPS.
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