A polydopamine peptide coating enables adipose-derived stem cell growth on the silicone surface of cochlear implant electrode arrays.
作者： Philipp Schendzielorz , Kristen Rak , Katrin Radeloff , Johannes Völker , Thomas Gehrke
DOI: 10.1002/JBM.B.33947
关键词: Neurotrophic factors 、 Biomedical engineering 、 Stem cell 、 Materials science 、 Coating 、 Electrode 、 Surface modification 、 Cell growth 、 Silicone 、 Viability assay
摘要: The simultaneous application of neurotrophic factors with cochlear implantation is proposed to enhance the bioelectrical interface between electrodes and auditory neurons, thus improve speech intelligibility in patients implants (CIs). In cell-based approaches, goal colonize CIs cells producing factors. This study aims evaluate whether a polydopamine (PD) functionalization hydrophobic silicone surface electrode carrier enables colonization adipose-derived stem known deliver Surface characteristics PD-coated samples carriers were determined, proliferation viability (ASCs) on these surfaces subsequently analyzed. A homogenous PD coating cell growth regular morphology was observed coated arrays. Hydrophilicity significantly enhanced by modification. Insertion forces arrays did not increase compared untreated CIs. Hence, might allow for sufficient ASCs as continuous source © 2017 Wiley Periodicals, Inc. J Biomater Res Part A: 106B: 1431-1438, 2018.
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