[Ca2+]i and Contraction of Arterial Smooth Muscle
DOI: 10.1007/978-1-4612-2596-6_8
关键词: Myosin 、 Biophysics 、 Serine 、 Phosphorylation 、 Smooth muscle contraction 、 Contraction (grammar) 、 Myosin light-chain kinase 、 Actin 、 Chemistry 、 Calmodulin
摘要: Most contractile stimuli induce arterial smooth muscle contraction by increasing myoplasmic [Ca2+] ([Ca2+]i). Ca2+ binds to calmodulin and activates myosin light chain kinase.1 The activated kinase phosphorylates the 20kDa of at serine 19 myosin’s ATPase.2 phosphorylated actin filaments, cycles, produces shortening and/or force.3 This is most widely accepted mechanism for regulation contraction. In this chapter, I will discuss in detail mechanisms regulating [Ca2+]i dependence force phosphorylation. also briefly altering phosphorylation on (ie, sensitivity phosphorylation).
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