Evaluation of the histo - gastroprotective and antimicrobial activities of heliotropium indicum linn (boraginaceae).

摘要: Heliotropium indicum of the family Boraginaceae is used locally in Nigeria to treat ailments such as ulcer and fever. In this study, ulceration gastric mucosa Wistar rats was induced via oral administration 80mg/kg/bodyweight Indomethacin. Histological analyses stomach body wall Groups 2 4 (which received 100mg/kg/bodyweight extract before Indomethacin only respectively) showed erosion mucus-secreting cells, pit, upper middle parts glands some parietal cells. observations Group 5 200mg/kg/bodyweight Indomethacin) pit most part gland. 1, 6 3 50mg/kg/bodyweight Ranitidine 400mg/kg/bodyweight Indomethacin; Normal Saline normal morphological appearance different components layer. Thus, aqueous extracts dried leaves have dose dependent histo-gastroprotective effects.