Chromosomal analysis in multiple myeloma : cytogenetic evidence of two different diseases

摘要: We report the cytogenetic results obtained in 81 multiple myeloma (MM) patients with abnormal karyotypes. Most karyotypes were complex numerical and structural abnormalities but analysis of chromosomal allowed identification two patterns depending on chromosome number: a first hyperdiploid pattern (54%) recurrent trisomies 3, 5, 7, 9, 11, 15 19 second (46%) showing either pseudodiploid, hypodiploid or near-tetraploid Structural present all five karyotypes, frequently involved lymphoid breakpoints: immunoglobulin gene regions (36 cases) 11q13 region (21 cases). Numerous other aberrations detected; most frequent 1 13. significantly more group. When analyzing 60 studied at time diagnosis, prognostic correlation was found between overall survival: had longer survival than belonging to pseudo/hypo/near-tetraploid group (median 36.8 vs 18.2 months, P < 0.04). These suggest that MM could correspond closely related diseases.