Protein kinases and multidrug resistance.

摘要: The role of protein kinases in the multidrug resistance phenotype cancer cell lines is discussed with an emphasis on kinase C and A. Evidence that P-glycoprotein phosphorylated by these summarised relationship between phosphorylation multidrug-resistant discussed. Results showing C, particularly alpha subspecies, overexpressed many MDR are described: this common but no means universal finding seems to be drug- line-dependent only a few cases there direct correlation activity resistance. From co-immunoprecipitation results it suggested specific receptor, as well being substrate. Revertant experiments provide conflicting expression C. A influences at gene level documented mechanisms which occurs becoming clarified. using inhibitors phorbol esters difficult interpret because such compounds bind P-glycoprotein. In spite huge effort, involvement regulating has not yet been firmly established. However, evidence PKC regulates Pgp-independent mechanism drug accumulating.