Dual endothelin receptor antagonism prevents remodeling of resistance arteries in diabetes.
作者： Kamakshi Sachidanandam , Vera Portik-Dobos , Aisha I. Kelly-Cobbs , Adviye Ergul
DOI: 10.1139/Y10-034
关键词: Matrix metalloproteinase 、 Endocrinology 、 Endothelin receptor 、 Blood vessel 、 Internal medicine 、 Diabetes mellitus 、 Bosentan 、 Circulatory system 、 Blockade 、 Medicine 、 Mesenteric arteries
摘要: Vascular remodeling, characterized by extracellular matrix deposition and increased media-to-lumen (M/L) ratio, contributes to the development of microvascular complications in diabetes. We have previously shown type 2 diabetic Goto–Kakizaki (GK) rats that selective ETA receptor blockade prevents medial thickening mesenteric arteries via regulation metalloproteases (MMP), whereas ETB augments this thickening. The goal study was determine effect combined on resistance vessel remodeling. Vessel structure, MMP activity, proteins were assessed control Wistar GK treated with vehicle or bosentan (100 mg/kg per day) for 4 weeks (n = 7–9 group). Bosentan completely prevented increase M/L ratio MMP-2 activity diabetes but paradoxically activation animals. Collagenase (MMP-13) protein levels significantly ...
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