Role of band 3 in the erythrocyte membrane structural changes under thermal fluctuations -multi scale modeling considerations.

摘要: An attempt was made to discuss and connect various modeling approaches on time space scales which have been proposed in the literature order shed further light erythrocyte membrane rearrangement caused by cortex-lipid bilayer coupling under thermal fluctuations. Roles of main constituents: (1) actin-spectrin cortex, (2) lipid bilayer, (3) trans protein band 3 their course-consequence relations were considered context cortex non linear stiffening corresponding anomalous nature energy dissipation. The fluctuations induce alternating expansion compression parts ensure surface volume conservation. structural changes within two regimes. results indicate that dissipation are related spectrin flexibility distribution rate its changes. varies from purely flexible semi flexible. It is influenced by: number molecules attached single filaments, phosphorylation actin-junctions. depends rearrangement.