Post-effects of radioactive decay in ligands on biologically active transport platforms

摘要: Abstract The electron capture consequences in the 57Co DOTA complex compound and processes of radiation-induced defect formation under effect recoil nuclei produced after α-decay 241Am were studied using high performance liquid radiochromatography emission Mossbauer spectroscopy. experiments conducted have shown that production targeted RPHs on base alpha-emitters when applying conventional approach (biologically active molecular construct with any chelate carrying a radioactive tracer) is just scientific mystification, since recoiling alpha-emitting nucleus causes destroying neighboring substrate molecules entirely excludes transport preparation. This bold conclusion indeed. However, it confirmed part by works other authors fact encapsulation α-particle emitters inorganic (rather than organic) nanocontainers significantly decreases negative carrier molecule allows radiation treatment to be done cancerous tissues, which similar hadron therapy. It (and not at all emitted alpha-particles) possess huge ability exert therapeutic alpha-emitters) are used. amount damage matrix, caused typical energy approximately 100 keV factor several hundreds higher 5–7 MeV α-particles. If labelled construction has reached tumor cell, there no doubt “prioritative” action as compared picture changes dramatically if impact “is blocked” location where an (e.g., nanocontainers). A success development pharmaceutical forms based possible only pernicious influence “blocked” owing stability compounds or “means transportation” radionuclides lesions. reasonable alternative might Auger- internal conversion (as present studies and, more importance, worldwide radionuclide practice) incomparably compounds.