The trigger matters - outcome of hepatorenal syndrome vs. specifically triggered acute kidney injury in cirrhotic patients with ascites.

摘要: BACKGROUND Hepatorenal syndrome (HRS) represents a severe form of renal injury in cirrhotic patients with ascites the absence certain triggers. METHODS Patients cirrhosis and were longitudinally screened for dysfunction. HRS was diagnosed by an increase serum creatinine (SCr) ≥100% to ≥1.5 mg/dl. If specific triggers (i.e. nephrotoxins, parenchymal kidney damage, hypovolaemia, infections) found, these cases defined as specifically triggered acute (sAKI). RESULTS Four hundred ninety-seven AKI we identified 71 84 sAKI. The most common sAKI damage 33%, nephrotoxins 30% hypovolaemia 29%. showed significantly more often complete remission than (51% vs. 13%, P < 0.001), whereas persisting impairment function (56% 37%, = 0.006). Short-term (30 days) mortality higher (62% 45%, 0.038). Remission rates varied between Transplant-free survival (TFS) not significantly, but numerically lower [14 (IQR: 2-99) 36 5-371) days; 0.102]. CONCLUSION show worse outcome 30-day AKI. Different seem influence prognosis. Prospective data are needed implement effective screening treatment algorithms ascites.