The immunologic response to injury.
作者： John A Mannick , Mary L Rodrick , James A Lederer
DOI: 10.1016/S1072-7515(01)01011-0
关键词: Immunity 、 Systemic inflammatory response syndrome 、 Inflammation 、 Immunology 、 Multiple organ dysfunction syndrome 、 Resuscitation 、 Thermal injury 、 Organ dysfunction 、 Medicine 、 Intensive care medicine 、 Shock (circulatory)
摘要: Research on the immune consequences of shock and trauma by multiple laboratories over more than 20 years has resulted in following paradigm, which is currently accepted most investigators this field: serious traumatic or thermal injury quickly followed, after initial resuscitation, systemic inflammatory response syndrome (SIRS) which, a sizeable minority patients, will lead inexorably to organ dysfunction (early MODS), with an attendant high mortality. The majority seriously injured patients survive SIRS without developing early MODS, period relative clinical stability, manifest compensatory antiinflammatory (CARS) suppressed immunity diminished resistance infection. Resultant infection its inflammation turn can (late MODS) death (Fig. 1). This paradigm several implications potential importance interpreting sometimes conflicting results research area:
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