Reversal of multidrug resistance in vitro by co-delivery of MDR1 targeting siRNA and doxorubicin using a novel cationic poly(lactide-co-glycolide) nanoformulation
作者： Ranjita Misra , Manasi Das , Bhabani Sankar Sahoo , Sanjeeb K. Sahoo
DOI: 10.1016/J.IJPHARM.2014.08.056
关键词: Multiple drug resistance 、 Doxorubicin 、 Chemistry 、 Poly lactide co glycolide 、 Cationic polymerization 、 Pharmacology 、 Drug resistance 、 In vitro 、 Nanocarriers 、 Drug
摘要: Over expression of drug efflux transporters such as P-glycoprotein (P-gp) cumulatively leading to multidrug resistance (MDR) embodies a major hindrance for successful cancer therapy. A paradigm nanomedicinal approach involving an anticancer and modulators within one multifunctional nanocarrier-based delivery system represent ideal modality the treatment MDR. In this regards, we have developed cationic polymeric nanoparticulate loaded with MDR1-siRNA doxorubicin. Results indicated augmented synergistic effect combinational nanoformulation in overcoming MDR MCF-7/ADR cells. Therefore, above regime could be promising co-delivery effective therapy resistant breast cancer.
elsevier.com
sci-hub.se 参考文章(61)
Jayanth Panyam, Vinod Labhasetwar, Dynamics of endocytosis and exocytosis of poly(D,L-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells. Pharmaceutical Research. ,vol. 20, pp. 212- 220 ,(2003) , 10.1023/A:1022219003551
Elmira Bajelan, Azadeh Haeri, Amir Masoud Vali, Seyed Nasser Ostad, Simin Dadashzadeh, Co-delivery of Doxorubicin and PSC 833 (Valspodar) by Stealth Nanoliposomes for Efficient Overcoming of Multidrug Resistance Journal of Pharmacy and Pharmaceutical Sciences. ,vol. 15, pp. 568- 582 ,(2012) , 10.18433/J3SC7J
Manasi Das, Chandana Mohanty, Sanjeeb K Sahoo, Ligand-based targeted therapy for cancer tissue Expert Opinion on Drug Delivery. ,vol. 6, pp. 285- 304 ,(2009) , 10.1517/17425240902780166
Kohei Tahara, Hiromitsu Yamamoto, Naohide Hirashima, Yoshiaki Kawashima, Chitosan-modified poly(d,l-lactide-co-glycolide) nanospheres for improving siRNA delivery and gene-silencing effects European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 74, pp. 421- 426 ,(2010) , 10.1016/J.EJPB.2009.12.007
Kim A. Woodrow, Yen Cu, Carmen J. Booth, Jennifer K. Saucier-Sawyer, Monica J. Wood, W. Mark Saltzman, Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA. Nature Materials. ,vol. 8, pp. 526- 533 ,(2009) , 10.1038/NMAT2444
Karin Corsi, Fatiha Chellat, Julio C Fernandes, None, Mesenchymal stem cells, MG63 and HEK293 transfection using chitosan-DNA nanoparticles. Biomaterials. ,vol. 24, pp. 1255- 1264 ,(2003) , 10.1016/S0142-9612(02)00507-0
Dhananjay Jere, Mi-Kyong Yoo, Rohidas Arote, Tae-Hee Kim, Myung-Haing Cho, Jae-Woon Nah, Yun-Jaie Choi, Chong-Su Cho, Poly (amino ester) Composed of Poly (ethylene glycol) and Aminosilane Prepared by Combinatorial Chemistry as a Gene Carrier Pharmaceutical Research. ,vol. 25, pp. 875- 885 ,(2008) , 10.1007/S11095-007-9448-4
Michael J. Campolongo, Dan Luo, Drug delivery: Old polymer learns new tracts. Nature Materials. ,vol. 8, pp. 447- 448 ,(2009) , 10.1038/NMAT2456
Daniel H. Kim, John J. Rossi, Strategies for silencing human disease using RNA interference. Nature Reviews Genetics. ,vol. 8, pp. 173- 184 ,(2007) , 10.1038/NRG2006
Xian-Zhu Yang, Shuang Dou, Tian-Meng Sun, Cheng-Qiong Mao, Hong-Xia Wang, Jun Wang, None, Systemic delivery of siRNA with cationic lipid assisted PEG-PLA nanoparticles for cancer therapy. Journal of Controlled Release. ,vol. 156, pp. 203- 211 ,(2011) , 10.1016/J.JCONREL.2011.07.035