DYRK2 controls the epithelial–mesenchymal transition in breast cancer by degrading Snail
作者： Rei Mimoto , Naoe Taira , Hiroyuki Takahashi , Tomoko Yamaguchi , Masataka Okabe
DOI: 10.1016/J.CANLET.2013.06.005
关键词: Cancer 、 Oncology 、 Snail 、 Biology 、 Kinase 、 Internal medicine 、 Epithelial–mesenchymal transition 、 Breast cancer 、 Cadherin 、 Gene knockdown 、 Cancer research 、 Metastasis
摘要: The epithelial-mesenchymal transition (EMT) plays a fundamental role in the early stages of breast cancer invasion. Snail, zinc finger transcriptional repressor, is an important regulator EMT. Snail phosphorylated by GSK3β and subsequently degraded βTrCP-mediated ubiquitination. We identified additional kinase, DYRK2, that regulates stability. Knockdown DYRK2 promoted EMT invasion vitro vivo. Consistent with these results, was found to be down-regulated human tissue. Patients low DYRK2-expressing tumors had worse outcome than those high tumors. These findings revealed metastasis degrading Snail.
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