Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over.

作者： Sean M. Baker , Annemieke W. Plug , Tomas A. Prolla , C. Eric Bronner , Allie C. Harris

DOI: 10.1038/NG0796-336

关键词: Chromosomal crossover 、 MLH1 、 DNA repair 、 Microsatellite instability 、 Biology 、 MLH3 、 PMS2 、 MSH2 、 DNA mismatch repair 、 Genetics

摘要: Mice that are deficient in either the Pms2 or Msh2 DNA mismatch repair genes have microsatellite instability and a predisposition to tumours. Interestingly, Pms2–deficient males display …

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