Patient Reported Outcomes in Rheumatoid Arthritis Clinical Trials

摘要: Patient reported outcomes (PRO) are at the core of assessing RA treatment response with patient assessments global health or disease activity, pain, and physical function included in calculation American College Rheumatology (ACR) responses. Progress has been made PROs that include additional patient-valued aspects recent randomized clinical trials (RCTs), particularly fatigue. Importantly, National Institute Health (NIH)--Patient Reported Outcomes Measurement Information System (PROMIS) development psychometrically advanced generic measures span range symptoms potentially affected RA, high precision across entire a symptom undergoing study other rheumatologic diseases to establish their construct validity, responsiveness, clinically meaningful cutoffs. PRO currently used widely available can provide important perspectives not captured composite criteria potential better informing decisions practice.