Investigating the temporal course, relevance and risk factors of fatigue over 5 years: a prospective study among patients receiving allogeneic HSCT

摘要: Although allogeneic hematopoietic stem cell transplantation (HSCT) features severe physical and psychological strain, no previous study has prospectively investigated fatigue beyond 3 years after transplantation. We the temporal course of over 5 years, compared patients with general population (GP) tested for treatment- complication-related risk factors. Patients were assessed before conditioning (T0, N=239) at 100-day (T1, N=150), 1-year (T2, N=102) 5-year (T3, N=45) follow-up. measured Multidimensional Fatigue Inventory-20. GP T0 T3. Global increased from to T1 (t=3.85, P<0.001), decreased T2 (t=−2. 92, P=0.004) then remained stable (t=0.45, P=0.656). No difference in global was found between T3 (t=0.68, P=0.497). Compared GP, showed higher (t=−6.02, P<0.001) (t=−2.50, P=0.014). These differences reached meaningful effect sizes (d⩾0.5). Acute chronic GvHD predicted (γ=0.34, P=0.006) (γ=0.38, P=0.010), respectively. To conclude, among HSCT improves time, finally returning pretransplantation levels. However, even remains relevant. are fatigue.