Toxicity of long-term exposure to oxides of sulfur.

摘要: Thirty-two beagles, 16 previously impaired with 191 days exposure to 26 ppM NO/sub 2/ (bullous alveolar enlargement, increased peribronchial and perialveolar reticulum fibers collagen), were exposed (1) control, (2) 5.1 SO/sub 2/, (3) approx. 900 ..mu..g/m/sup 3/ H/sub 2/SO/sub 4/ (90% < 0.5 ..mu..m), or (4) combination of 2 3, for 620 days, 21 hr/day. No effect x/ on hematology lung measurements. nitrogen washout in unimpaired animals but lowered animals. significantly reduced CO diffusing capacity, net inflated volume, deflated weight, residual total expiratory resistance. Decreased heart weight was also noted. Impairment trapped air. Lung altered more difficult alter more. at low levels can produce serious pulmonary impairment, is dangerous than 2/.