Candidate novel long noncoding RNAs, MicroRNAs and putative drugs for Parkinson's disease using a robust and efficient genome-wide association study.
作者： Zahra Mortezaei , Hossein Lanjanian , Ali Masoudi-Nejad
DOI: 10.1016/J.YGENO.2017.02.004
关键词: Disease 、 Biology 、 Parkinson's disease 、 Long non-coding RNA 、 Genetic association 、 Single-nucleotide polymorphism 、 Candidate gene 、 Genome-wide association study 、 Genetics 、 Linkage disequilibrium
摘要: Parkinson's disease (PD) is a neurodegenerative disorder with serious symptoms of which, are not clearly demonstrated at the beginning stages disease, making treatment challenging. Understanding genetic causes PD can be useful for determining its mechanisms and proposing treatments preventive methods. For different populations backgrounds lifestyles, genome-wide association studies (GWASs) represent crucial approach analysis. In this study, robust efficient GWAS without dimensionality reduction applied to evaluate heritability in German US populations. The results show higher rate population. Moreover, 25 significant SNPs have been determined, as well five newly identified candidate genes associated some potential drug candidates. Analysis also reveals various long noncoding RNAs (lncRNAs), microRNAs transcription-factor binding sites (TFBSs) prevention PD.
sci-hub.se 参考文章(58)
Yue Huang, Piu Chan, Glenda Halliday, Chapter 28 – Genetics of Parkinson's Disease Oxidative Stress and Neurodegenerative Disorders. pp. 663- 697 ,(2007) , 10.1016/B978-044452809-4/50169-1
Teresa Giraldez, Jaime Dominguez, Diego Alvarez de la Rosa, ENaC in the brain--future perspectives and pharmacological implications. Current Molecular Pharmacology. ,vol. 6, pp. 44- 49 ,(2013) , 10.2174/1874467211306010006
Nada Milosevic, Benjamin Kühnemuth, Leonie Mühlberg, Stefanie Ripka, Heidi Griesmann, Carolin Lölkes, Malte Buchholz, Daniela Aust, Christian Pilarsky, Sebastian Krug, Thomas Gress, Patrick Michl, Synthetic lethality screen identifies RPS6KA2 as modifier of epidermal growth factor receptor activity in pancreatic cancer. Neoplasia. ,vol. 15, pp. 1354- 1362 ,(2013) , 10.1593/NEO.131660
Robert Vink, Mihai Nechifor, None, Magnesium in the Central Nervous System ,(2011)
Nan M. Laird, Christoph Lange, The Fundamentals of Modern Statistical Genetics ,(2010)
Donald E. Frail, Michael J. Barratt, Drug Repositioning: Bringing New Life to Shelved Assets and Existing Drugs ,(2012)
M.D. Ramos, D. Trujillano, R. Olivar, F. Sotillo, S. Ossowski, J. Manzanares, J. Costa, S. Gartner, C. Oliva, E. Quintana, M.I. Gonzalez, C. Vazquez, X. Estivill, T. Casals, Extensive sequence analysis of CFTR, SCNN1A, SCNN1B, SCNN1G and SERPINA1 suggests an oligogenic basis for cystic fibrosis-like phenotypes. Clinical Genetics. ,vol. 86, pp. 91- 95 ,(2014) , 10.1111/CGE.12234
Matthias Elstner, Christopher M. Morris, Katharina Heim, Peter Lichtner, Andreas Bender, Divya Mehta, Claudia Schulte, Manu Sharma, Gavin Hudson, Stefano Goldwurm, Alessandro Giovanetti, Massimo Zeviani, David J. Burn, Ian G. McKeith, Robert H. Perry, E. Jaros, Rejko Krüger, H.-Erich Wichmann, Stefan Schreiber, Harry Campbell, James F. Wilson, Alan F. Wright, Malcolm Dunlop, Giorgio Pistis, Daniela Toniolo, Patrick F. Chinnery, Thomas Gasser, Thomas Klopstock, Thomas Meitinger, Holger Prokisch, Douglass M. Turnbull, Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene. Annals of Neurology. ,vol. 66, pp. 792- 798 ,(2009) , 10.1002/ANA.21780
Minghui Wang, Lin Wang, Ning Jiang, Tianye Jia, Zewei Luo, A robust and efficient statistical method for genetic association studies using case and control samples from multiple cohorts BMC Genomics. ,vol. 14, pp. 88- 88 ,(2013) , 10.1186/1471-2164-14-88
Minghui Wang, Tianye Jia, Ning Jiang, Lin Wang, Xiaohua Hu, Zewei Luo, Inferring linkage disequilibrium from non-random samples† BMC Genomics. ,vol. 11, pp. 328- 328 ,(2010) , 10.1186/1471-2164-11-328