PI3K-Akt-Wnt Pathway Is Implicated in Exercise-Induced Improvement of Short-term Memory in Cerebral Palsy Rats.
作者： Jung-Wan Cho , Sun-Young Jung , Dae-Young Kim , Yong-Rak Chung , Hyun-Hee Choi
关键词: Memory improvement 、 Neurogenesis 、 Internal medicine 、 Protein kinase B 、 Medicine 、 PI3K/AKT/mTOR pathway 、 Endocrinology 、 Synaptic plasticity 、 Wnt signaling pathway 、 Hippocampal formation 、 Cerebral palsy
摘要: PURPOSE Maternal lipopolysaccharide (LPS) injection induces neurodevelopmental disorders, such as cerebral palsy. Exercise activates phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt) signaling pathway that enhances neurogenesis. Wnt ligands are also implicated in the hippocampal neurogenesis and synaptic plasticity. Glycogen synthase kinase-3β (GSK-3β) is a downstream molecule of Akt, GSK-3β known to modulate negatively. METHODS Cerebral palsy was made by maternal LPS-injection. On 5 weeks after birth, treadmill running applied rat pups exercise groups, for 30 minutes, times week during 6 weeks. RESULTS Treadmill alleviated short-term memory impairments pups. Hippocampal cell proliferation increased apoptosis suppressed phosphorylated-PI3K/PI3K ratio, phosphorylated-Akt/Akt expression were enhanced In contrast, phosphorylated-GSK-3β/GSK-3β ratio β-catenin CONCLUSION The results this study showed improvement due occurs via activation PI3K-Akt-Wnt pathway.
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