Biogenesis of pigment granules: a sensitive way to regulate melanocyte function

摘要: Pigmentation not only provides a wide range of cosmetic coloration to the skin, hair and eyes, but also underlying tissue significant protection from ultraviolet (UV) damage, which can lead photoaging photocarcinogenesis. The melanin pigment is synthesized deposited within unique, membrane-bound organelle termed melanosome. Recent advances in molecular biology biochemistry have allowed greater appreciation how melanocytes generate this its biogenesis, structure function regulated by environment. Melanosomes serve as ideal models for study protein trafficking, movement cell-cell interactions that occur during transfer melanosomes keratinocytes. Our understanding mechanisms behind human pigmentary diseases grown remarkably been unraveled.