Epigenetics in Kidney Transplantation

摘要: Epigenetic modifications are changes to the genome that occur without any alteration in DNA sequence. These include cytosine methylation of at cytosine-phosphate diester-guanine dinucleotides, histone modifications, microRNA interactions, and chromatin remodeling complexes. may exert their effect independently or complementary genetic variants have potential modify gene expression. dynamic, potentially heritable, can be induced by environmental stimuli drugs. There is emerging evidence epigenetics play an important role health disease. However, impact epigenetic on outcomes kidney transplantation currently poorly understood deserves further exploration. Kidney best treatment option for end-stage renal disease, but allograft loss remains a significant challenge leads increased morbidity return dialysis. influence activation, proliferation, differentiation immune cells, therefore critical host response its outcome. The epigenome donor also graft survival, especially those associated with early transplant stressors (e.g., cold ischemia time) aging. In present review, we discuss supporting ischemia-reperfusion injury, graft, injury as new tools diagnosis prediction function, therapeutic targets improving transplantation.