Hemoglobinopathies and sleep e The road less traveled

摘要: summary Sickle cell disease and thalassemia are common hereditary blood disorders associated with increased systemic inflammation, tissue hypoxia, endothelial dysfunction end-organ damage, the latter accounting for substantial morbidity abbreviated lifespan these conditions. Sleep perturbations in general, sleep-disordered breathing particular also highly prevalent conditions mechanisms underlying their widespread morbidities markedly intriguingly overlap very same pathways implicated hemoglobinopathies. However, little attention has been given to date potential contributing role of sleep sickle manifestations. Here, we comprehensively review pathophysiological clinical manifestations linking disturbed hemoglobinopathies, special emphasis on disease. In addition a broad available evidence, identify many research gaps that require future investigation, provide scientific contextual setting should enable opportunities investigate intertwined outcomes