Mitochondrial Dysfunction Signature in Diabetic Vascular Endothelium
作者： Lucia Doina Popov
DOI: 10.4172/2161-0681.1000334
关键词: Disease 、 Bioinformatics 、 Basic research 、 Endothelium 、 Medicine 、 Risk factor 、 Endothelial dysfunction 、 Vascular endothelium 、 Diabetes mellitus 、 Mitochondrial ROS
摘要: Mitochondrial dysfunction/malfunction is an important risk factor for the onset and progression of endothelial cells dysfunction, a key contributor to diabetes mellitus associated cardiovascular disease. The topics discussed here are: (i) regulatory role mitochondrial ROS in normal, healthy vascular endothelium, (ii) adverse alteration function diabetes-related (iii) endeavors towards correction malfunction dysfunctional (iv) points mitochondria-targeted interventions diabetic patients, (v) pending, incompletely understood issues that open new basic research directions may conduct innovative therapeutic strategies diabetes.
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